Technically termed Renal Nephropathy, Kidney Disease is an inevitable result of the chronically uncontrolled blood Glucose and chronic high Insulin levels that are associated with Hyperinsulinemia and Type 2 diabetes.
The Kidneys are system filters whose purpose is to filter out the water soluble waste materials in the blood, to mix them with an appropriate amount of water to form urine and to send this mixture to the bladder for excretion from the body. They do this in a way that conserves blood components that may be needed for future use. Thus the Kidneys return non-waste blood components to the blood stream to maintain proper blood Homeostasis, they control the blood PH to within very tight limits (7.35-7.45), they control the water Electrolyte blood balance and they, through the action of Renin-Angiotensis mechanism and the excretion of water from the system, play an important role in the operation of the Blood Pressure Control System (BPCS). This BPCS is another of the bodies' control systems similar to, but not directly related to, the Blood Sugar Control System.
In structure the Kidneys consist largely of many fine capillaries through which the blood flows during the filtration process. A number of complex osmotic reactions occur during the passage of blood through the Kidneys that are driven by the Electrolyte balance in the blood and by the osmatic pressure differentials caused by the Sodium Potassium balance in the blood stream.
When Renal Failure occurs, Dialysis is required or death will ensue in short order, typically 50% within six months and most by one year. Dialysis is a procedure whereby the blood is externally filtered through a machine especially designed for the purpose. When this procedure is done periodically the blood stream is filtered of impurities. By the use of this method life may be prolonged after Kidney Failure is experienced.
There are three major damage mechanisms by which progressive deterioration of the Kidneys occurs.
The first is by direct damage of the fine capilaries by the high Glucose levels associated with Diabetes and with Hyperinsulinemia. The glucose directly causes an increased permeability and the capillaries leak and fail to perform their filtering action. Severe and extensive damage to these fine capilliaries is thought to be irreversable at this time.
A leading cause of Renal Failure for the Hyperinsulinemic patient is Renal Thrombosis (blood clotting in the Renal vein).
The high levels of Insulin in the blood directly cause Atherosclerosis of the Renal artery. This mechanism is discussed on our Atherosclerosis page.
A related complicating factor is caused by the high levels of dietary protein to which many sufferers from Diabetes and Hyperinsulinemia resort. This protein, when it is metabolized, results in high levels of Ammonia . Chronic high levels of Ammonia, mostly changed into Urea by the Liver, nevertheless directly damage the fine capillaries. Also there are known other negative effects in the tubular basement membranes of the Kidneys that are directly caused by certain proteins.
Unless normal blood Glucose levels can be maintained without resorting to a high protein diet, the progress of Hyperinsulinemia and its related Type II diabetes invariably leads to Renal (Kidney) failure and the need for Dialysis. In our special report Insulin: Our Silent Killer we thoroughly discuss the dietary factors that are especially important to the diabetic. This High Protein-Kidney Damage relationship is potentially one of the most important to the recovering diabetic. During the recovery process, which may last for several months, it isn't smart to wreck the Kidneys by resorting to a high protein diet. This is uniquely important because, while much of the damage done by Type II diabetes and Hyperinsulinemia is reversable, all of it is not. In particular when the basement membranes of the Kidneys are destroyed, the destruction is currently thought to be irreversable.
High blood pressure, Hypertension, which is often found in progressive Renal Failure, is also one of the characteristics of Hyperinsulinemia. If there is any suspicion that Hyperinsulinemia or Type II diabetes, may exist, one should have a blood test done and obtain medical advice based on the BUN and Creatine levels found in the test with regard to possible Kidney damage.
On the next page where we discuss Hyperinsulinemia, we discuss ways in which this disease can be readily prevented from progressing. We include below a starter list of references for those who want to look at the original data. Much more information about Hyperinsulinemia is available in our Special Report than can conveniently be put on this web site.
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